Tubulin binding ligands and corresponding prodrug constructs

US7091240B2 · kind B2 · utility

Assignees

• OXiGENE, Inc. · US
• Baylor University · US

Inventors

• Kevin G. Pinney · Woodway, US
• Vani P. Mocharla · Los Angeles, US
• Zhi Chen · Seattle, US
• Charles Garner · Waco, US
• Mallinath Hadimani · Waco, US
• Raymond Kessler · Saginaw, US
• James M. Dorsey · Havertown, US
• Klaus Edvardsen · Klampenborg, DK
• David Chaplin · Aston Rowant, GB
• Joseph Prezioso · Boston, US
• Anjan Ghatak · Salt Lake City, US

Key dates

• Filing date: Apr 29, 2003
• Grant date: Aug 15, 2006
• Expiry date: May 25, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A diverse set of tubulin binding agents have been discovered which are structurally characterized, in a general sense, by a semi-rigid molecular framework capable of maintaining aryl-aryl, pseudo pi stacking distances appropriate for molecular recognition of tubulin. In phenolic or amino form, these ligands may be further functionalized to prepare phosphate esters, phosphate salts, phosphoramidates, and other prodrugs capable of demonstrating selective targeting and destruction of tumor cell vasculature.