IL-3 variant hematopoiesis fusion protein

US7091319B1 · kind B1 · utility

Inventors

• S. Christopher Bauer · New Haven, US
• Mark Allen Abrams · Chesterfield, US
• Sarah Ruth Braford-Goldberg · Chesterfield, US
• Marie Helena Caparon · Chesterfield, US
• Alan Michael Easton · Maryland Heights, US
• Barbara Kure Klein · Eureka, US
• John McKearn · Park Hills, US
• Peter O. Olins · Park Hills, US
• Kumnan Paik · Wilmette, US
• John Warren Thomas · Eureka, US

Key dates

• Filing date: Jun 6, 1995
• Grant date: Aug 15, 2006
• Expiry date: Jun 6, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention relates to fusion molecules composed of human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally joined to a second colony stimulating factor (CSF), cytokine, lymphokine, interleukin or IL-3 variant. These hIL-3 variants contain amino acid substitutions and may also have amino acid deletions at both the N- and C-termini. The invention also relates to pharmaceutical compositions containing the fusion molecules and methods for using them.