Human TIMP-1 antibodies

US7091323B2 · kind B2 · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Clark Pan · Sudbury, US
• Andreas M. Knorr · Erkrath, DE
• Michael Schauer · Wuppertal, DE
• Claudia Hirth-Dietrich · Wuppertal, DE
• Sabine Kraft · Planegg, DE
• Barbara Krebs · Bensberg, DE

Key dates

• Filing date: Apr 24, 2002
• Grant date: Aug 15, 2006
• Expiry date: Apr 11, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/76
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Human antibodies that bind to TIMP-1 can be used as reagents to diagnose and treat disorders in which TIMP-1 is elevated, such as liver fibrosis, alcoholic liver disease, cardiac fibrosis, acute coronary syndrome, lupus nephritis, glomerulosclerotic renal disease, benign prostate hypertrophy, colon cancer, lung cancer, and idiopathic pulmonary fibrosis.