Process for synthesizing N-aryl piperazines with chiral N′-1-[benzoyl(2-pyridyl)amino]-2-propane substitution
US7091349B2 · kind B2 · utility
2Cited by
4References
5Claims
0Family size
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Key dates
| Filing date | Feb 18, 2004 |
| Grant date | Aug 15, 2006 |
| Priority date | — |
| Expiry date | Apr 14, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D319/18
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for formation of N-aryl piperazines with chiral N′-1-[benzoyl(2-pyridyl)amino]-2-propane side-chains having the structure shown in formula below, and for making intermediate compounds therefor.In this process, chirality is introduced at the piperazine ring formation step and 2-aminopyridyl substitution is incorporated via displacement. The resulting N, N′ disubstituted piperazines act on the central nervous system at 5HT receptors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.