Methods of MHC class II epitope mapping, detection of autoimmune T cells and antigens, and autoimmune treatment
US7094555B2 · kind B2 · utility
22Cited by
5References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 5, 2002 |
| Grant date | Aug 22, 2006 |
| Priority date | — |
| Expiry date | Apr 27, 2022 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/24
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides of using multimeric MHC class II/peptide complexes. In one aspect, methods provided for identifying MHC class II-restricted immune epitopes of a predetermined polypeptide antigen. Methods for identifying an immunostimulatory epitope for a predetermined polypeptide antigen are provided. In a related aspect, methods for screening a therapeutic polypeptide agent for an MHC class II epitope are provided. In other aspects, methods for modulating T cells and for determining or monitoring an MHC class II-restricted immune status of a patient are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.