Formation of polyampholytes in the presence of a polyion
US7094605B2 · kind B2 · utility
3Cited by
2References
19Claims
0Family size
Assignee
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Key dates
| Filing date | Jan 28, 2005 |
| Grant date | Aug 22, 2006 |
| Priority date | — |
| Expiry date | Jul 26, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/88
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Polyampholyte are able to condense nucleic acid to form small complexes which can be utilized in the delivery of nucleic acid to mammalian cells. The polyampholytes can be formed prior to interaction with nucleic acid or they can be formed in the presence of nucleic acid. Stabilized polycation/nucleic acid complexes can be modified to reduce the positive charge of the polycation and add targeting ligands without destabilizing the complex. The resultant particles retain their small size and are more effective in delivery of nucleic acid to cells in vivo.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.