Complexes comprising a prion protein and a peptidyl prolyl isomerase chaperone, and method for producing and using them

US7094757B2 · kind B2 · utility

Assignee

• Roche Diagnostics GMBH · DE

Inventors

• Elke Faatz · Huglfing, DE
• Christian Scholz · Penzberg, DE
• Werner Stock · Gräfelfing, DE
• Peter Schaarschmidt · Ulm, DE

Key dates

• Filing date: Dec 23, 2003
• Grant date: Aug 22, 2006
• Expiry date: Sep 22, 2024

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/2821
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention relates to the diagnosis of transmissible spongiform encephalopathies (TSEs). It especially teaches the production of a soluble prion protein (PrP)-chaperone complex and the advantageous use of such chaperone-PrP complex, especially in the detection of PrP in an immunoassay, as well as its use as and immunogen.