Soluble complexes of amylod β peptide and peptidyl prolyl isomerase chaperone and methods of making and using them

US7094884B2 · kind B2 · utility

Assignee

• Roche Diagnostics GMBH · DE

Inventors

• Christian Scholz · Penzberg, DE
• Elke Faatz · Huglfing, DE
• Peter Schaarschmidt · Ulm, DE

Key dates

• Filing date: May 22, 2003
• Grant date: Aug 22, 2006
• Expiry date: Mar 8, 2024

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/2821
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention relates to the diagnosis of Alzheimer's Disease. It especially teaches the production of a soluble Aβ-chaperone complex and the advantageous use of such chaperone-Aβ complex, especially in the detection of Aβ in an immunoassay, as well as its use as an immunogen.