Injectable aqueous dispersions of propofol

US7097849B2 · kind B2 · utility

Assignee

• JAGOTEC AG · CH

Inventors

• Awadhesh Mishra · Westmount, CA
• Gary W. Pace · Winchester, US
• Michael Vachon · Keyano, CA

Key dates

• Filing date: Aug 18, 1999
• Grant date: Aug 29, 2006
• Expiry date: Jun 13, 2020

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Irritation upon injection of a formulation containing propofol is reduced or substantially eliminated by administering a stable, sterile, and antimicrobial aqueous dispersion comprising a water-insoluble microdroplet matrix of mean diameter from about 50 nm to about 1000 nm consisting essentially of about 1% to about 15% of propofol, up to about 7% of a propofol-soluble diluent, and about 0.8% to about 4% of a surface stabilizing amphiphilic agent. The aqueous phase includes a pharmaceutically acceptable water-soluble polyhydroxy tonicity modifier. The propofol-containing dispersion is devoid of additional bactericidal or bacteriostatic preservative agents.