Methods of screening test compounds using GADD34L, an eIF2α-specific phosphatase subunit
US7097996B2 · kind B2 · utility
3Cited by
1References
31Claims
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Key dates
| Filing date | Aug 28, 2003 |
| Grant date | Aug 29, 2006 |
| Priority date | — |
| Expiry date | Jul 26, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/42
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention is directed to methods and reagents for identifying test substances useful for the prevention or treatment of diseases involving an oxidative stress. The methods involve screening assays, including high throughput screening techniques, in which the test substances are tested for their ability to promote resistance to oxidative stress by inhibiting the activity of GADD34L, and thereby inhibiting the dephosphorylation of eIF2α, while not causing stress.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.