Natural promoters for gene expression in C1 metabolizing bacteria
US7098005B2 · kind B2 · utility
15Cited by
2References
5Claims
0Family size
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Key dates
| Filing date | Oct 14, 2005 |
| Grant date | Aug 29, 2006 |
| Priority date | — |
| Expiry date | Oct 14, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/195
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Genes have been identified in the Methylomonas genome that are responsive to various metabolic and growth conditions. The identified responsiveness of these genes allows for the use of their promoters in regulated gene expression in C1 metabolizing bacteria. In particular, the hps promoter, which in its native state drives the expression of 3-hexulose-6-phosphate synthase (HPS), was found to be useful for directing expression of heterolgous coding regions (e.g., crtZ) in the obligate methanotroph Methylomonas sp. 16a.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.