Transgenic mouse expressing constitutively active hydrocarbon receptor
US7098376B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 25, 2001 |
| Grant date | Aug 29, 2006 |
| Priority date | — |
| Expiry date | Oct 25, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K2267/0331
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention makes available powerful tools for the study of cancer, based on a novel expression construct for a constitutively active hydrocarbon receptor CA-AhR. The invention further comprises transgenic non-human animals, preferably mammals, expressing CA-AhR in one or more tissues thereof. An animal model based on the transgenic non-human animals forms the basis for novel methods e.g. for the study of cancer; for the screening of compounds, such as drug candidates; for the investigation of the molecular mechanisms of cancer, in particular stomach cancer; for the investigation of the mechanisms of highly differentiated adenocarcinoma etc. Likewise, in vitro models based on transformed cells or cell lines, functionally incorporating the inventive construct are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.