Targeted retrograde gene delivery to motor neurons
US7101540B2 · kind B2 · utility
5Cited by
3References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 5, 2002 |
| Grant date | Sep 5, 2006 |
| Priority date | — |
| Expiry date | Apr 20, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2750/14143
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods are disclosed for delivering a heterologous gene to a cell body of a neuron by contacting a muscle tissue innervated by the neuron with a viral vector comprising a heterologous gene, wherein the viral vector enters said neuron and is retrogradely moved to the cell body. Additionally, methods for expressing secreted proteins from a nerve cell body as well as methods for treating neurodegenerative disorders such as amyotrophic lateral sclerosis are described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.