Hematopoietic cell composition for use in transplantation
US7101708B1 · kind B1 · utility
11Cited by
1References
8Claims
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Key dates
| Filing date | Jul 20, 1999 |
| Grant date | Sep 5, 2006 |
| Priority date | — |
| Expiry date | Jul 20, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2502/1394
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Cell compositions consisting essentially of mammalian hematopoietic CXCR4+ stem and progenitor capable to migrate in response to stromal-derived factor 1 (SDF-1) and/or capable to adhere to stromal cells in response to an adhesion-inducing agent, are provided for clinical transplantation. Hematopoietic CXCR4−/low stem and progenitor cells can be converted into CXCR4+ cells by stimulation with a suitable agent. The composition consists preferably of human CD38−/low CXCR44 cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.