Polymeric drug formulations
US7101840B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 21, 2002 |
| Grant date | Sep 5, 2006 |
| Priority date | — |
| Expiry date | Jun 15, 2023 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/7007
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of forming a polymeric drug formulation in which a water-soluble drug is blended with a water-insoluble tissue-compatible polymer that is miscible in the solid phase with the drug, and with a poly(alkylene oxide), in a solvent system capable of forming a homogeneous solution of the drug, the tissue-compatible polymer and the poly(alkylene oxide), after which the solution is added to a non-solvent for the drug, the tissue-compatible polymer and the poly(alkylene oxide), so that a microdomain-separated solid co-precipitate of the drug, the tissue-compatible polymer and the poly(alkylene oxide) is formed, wherein the poly(alkylene oxide) is blended in an amount effective to form phase-separated microdomains in said co-precipitate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.