Method and composition for inhibition of angiogenesis using antagonists based on MMP-9 and β1 integrins
US7101975B1 · kind B1 · utility
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17Claims
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Key dates
| Filing date | Jul 13, 2000 |
| Grant date | Sep 5, 2006 |
| Priority date | — |
| Expiry date | Oct 1, 2022 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/96486
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Antagonists for modifying protein-protein interactions involving certain amino acid sequences within MMP-9 and/or β1 integrins are described. Such antagonists inhibit angiogenesis, tumor growth and disease states. Example antagonists are polypeptide and non-polypeptide molecules, including the novel antibody Mab FM155 and the novel synthetic peptide FRIP-1. Methods for inhibiting angiogenesis and disease states by administering such antagonists are disclosed. Methods for identifying antagonists that modify protein-protein interactions involving certain amino acid sequences within MMP-9 and/or β1 integrins are also described.
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