Method of using an adenoviral vector encoding a retinoblastoma protein to treat hyperproliferating cells

US7105156B1 · kind B1 · utility

Assignees

• The Regents of the University of California · US
• Canji, Inc. · US

Inventors

• Wen-Hwa Lee · San Diego, US
• H. Michael Shepard · San Diego, US
• Richard Gregory · Westford, US
• Ken Wills · Encinitas, US
• Daniel C. Maneval · San Diego, US
• Eva Lee · San Diego, US
• David Goodrich · Houston, US
• Nan Wang · Shanghai, CN

Key dates

• Filing date: Jun 7, 1995
• Grant date: Sep 12, 2006
• Expiry date: Jun 7, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2710/10043
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are methods of controlling cell cycle progression by introducing into a cell to be controlled a composition selected from the group consisting of p56RB protein, a fragment of the p56RB protein, and the gene encoding p56RB protein to alter the cell cycle progression while maintaining the viability of the cell. The p56RB protein has been found to have the unexpected and surprising characteristic of being soluble in low concentrations of glycerol, thereby enhancing its value in pharmaceutical applications and the gene encoding p56RB when delivered to the hyperproliferating cell inhibits cellular proliferation.