Pharmaceutical composition for immunomodulation based on peptides and adjuvants

US7105162B1 · kind B1 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Walter Schmidt · Wien, AT
• Max L. Birnstiel · Wien, AT
• Peter Steinlein · Wien, AT
• Michael Buschle · Perchtoldsdorf, AT
• Tamás SCHWEIGHOFFER · Riehen, CH

Key dates

• Filing date: Feb 21, 1997
• Grant date: Sep 12, 2006
• Expiry date: Feb 21, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/16134
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pharmaceutical composition containing at least one peptide or protein (fragment) with an immunomodulatory activity together with an adjuvant. The peptide is derived from a pathogenic agent or a tumour antigen. The adjuvant is capable of increasing the binding of the peptide to the cells of the individual to be treated or of increasing the entry of the peptide into the cells and strengthening the immunomodulatory activity of the peptide. Preferred adjuvants are basic polyamino acids such as polyarginine or polylysine, optionally conjugated with a cellular ligand such as a carbohydrate group or transferrin. The composition is particularly intended for use as a vaccine, e.g. as a tumour vaccine.