Phosphinic pseudopeptide derivatives for the selective inhibition of the C-terminal active site of angiotensin I converting enzyme (ACE)

US7105483B2 · kind B2 · utility

Assignee

• COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES · FR

Inventors

• Joel Cotton · Orsay, FR
• Dimitri Georgiadis · Athens, GR
• Vincent Dive · Palaiseau, FR

Key dates

• Filing date: Jan 16, 2003
• Grant date: Sep 12, 2006
• Expiry date: Jan 16, 2023

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to the use of phosphinic pseudopeptide derivatives for production of a medicament for selectively inhibiting the active C-terminal site of angiotensin I converting enzyme. These derivatives are of formula (II):where, R1 may be a protecting group for amino functions usually used in peptide chemistry or an amino acid or a peptide protected by the above type of protecting groups, R2 and R3 correspond to a natural or unnatural amino acid side chain and R4 and R5 represent a hydrogen atom or a counterion.