Methods and compositions for inhibiting angiogenesis
US7105496B2 · kind B2 · utility
3Cited by
9References
2Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 25, 2003 |
| Grant date | Sep 12, 2006 |
| Priority date | — |
| Expiry date | Apr 13, 2024 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/57484
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous PEDF to cells associated with the tissue. The presence of exogenous PEDF inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor be assaying for the presence of PEDF within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of PEDF.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.