Patent · US Expired

Aryl substituted pyridines and the use thereof

US7105549B2 · kind B2 · utility

45Cited by

52References

29Claims

0Family size

Assignee

Euro-Celtique S.A. · LU

Inventors

Bin Shao · Shanghai, CN
R. Richard Goehring · Pipersville, US
Samuel Victory · Oak Ridge, US
Qun Sun · Princeton, US

Key dates

Filing date	Sep 6, 2002
Grant date	Sep 12, 2006
Priority date	—
Expiry date	Jul 23, 2023

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10T436/145555
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

This invention relates aryl substituted pyridines of Formula I:or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R1–R4 are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.