2,4-disubstituted thiazolyl derivatives

US7105550B2 · kind B2 · utility

Inventors

• Christopher John Love · Deurne, BE
• Jean Pierre Frans Van Wauwe · Beerse, BE
• Marc De Brabander · Zoersel, BE
• Ludwig Paul Cooymans · Beerse, BE
• Nele Vandermaesen · Olmen, BE
• Ludo Edmond Josephine Kennis · Lier, BE

Key dates

• Filing date: Feb 20, 2001
• Grant date: Sep 12, 2006
• Expiry date: Aug 13, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention concerns the use of a compound of formula (I′)a N-oxide, pharmaceutically acceptable addition salt, quaternary amine and stereochemically isomeric form thereof, wherein Q is optionally substituted C3-6cycloalkyl, phenyl, naphthyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, benzthiazolyl, benzoxazolyl, benzimidazolyl, indazolyl, or imidazopyridyl; or Q is a radical of formulawherein X and Y each independently are O, NR3, CH2 or S, with R3 being hydrogen or C1-4alkyl; q is 1 to 4; Z is O or NR4 with R4 being hydrogen or C1-4alkyl; r is 1 to 3; L is optionally substituted phenyl or L is Het with Het being an optionally substituted five- or six-membered heterocyclic ring or an optionally substituted bicyclic heterocyclic ring; for the manufacture of a medicament for the prevention or the treatment of diseases mediated through cytokines.