Stabilization of envelope glycoprotein trimers by disulfide bonds introduced into a gp41 glycoprotein ectodomain
US7105655B2 · kind B2 · utility
3Cited by
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10Claims
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Key dates
| Filing date | Jun 25, 2002 |
| Grant date | Sep 12, 2006 |
| Priority date | — |
| Expiry date | Aug 7, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/16122
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present application is directed to stabilized envelope glycoprotein trimers. The trimers are stabilized by introducing disulfide bonds at certain sites in the gp41 ectodomain. DNA molecules encoding such trimers can be used to generate an immunogenic reaction.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.