Method of producing N-substituted 2,6-dialkylmorpholines

US7105662B2 · kind B2 · utility

Assignee

• BASF SE

Inventors

• Michael Henningsen · Bischofswerda, DE
• Andreas Kusche · Kleinfischlingen, DE
• Michael Hullmann · Bensheim, DE
• Lothar Rub · Speyer, DE
• Stefan Käshammer · Schifferstadt, DE
• Till Gerlach · Ludwigshafen, DE

Key dates

• Filing date: Mar 15, 2002
• Grant date: Sep 12, 2006
• Expiry date: Mar 21, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D295/03
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a process for the preparation of N-substituted 2,6-dialkylmorpholines of the formula Iin which R1 and R2, independently of one another, are hydrogen, alkyl or cycloalkyl, or R1 and R2 together with the carbon atom to which they are bonded are a 5- to 14-membered carbocycle, and R3 and R4, independently of one another, are alkyl or cycloalkyl, by reacting at least one carbonyl compound of the formula IIin which R1 and R2 have the meanings given above, with at least one morpholine of the formula IIIin which R3 and R4 have the meanings given above, in the presence of hydrogen and at least one metal-containing catalyst, wherein the active component of the catalyst consists essentially of platinum group metals.