Boat tropanes
US7105678B2 · kind B2 · utility
2Cited by
19References
12Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Oct 11, 2001 |
| Grant date | Sep 12, 2006 |
| Priority date | — |
| Expiry date | Oct 11, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K51/0448
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Radiopharmaceutical compounds are disclosed. A tropane compound is linked through the N atom at the 8-position to a chelating ligand capable of complexing technetium or rhenium to produce a neutral labeled complex that selectively binds to the dopamine transporter over the serotonin transporter with a ratio of 10 or more. These compounds can be prepared as separate diastereoisomers as well as a mixture of diastereoisomers. Also disclosed are radiopharmaceutical kits for preparing the labeled radiopharmaceutical compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.