High-resolution virus removal methodology and filtration capsule useful therefor
US7108791B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 15, 2002 |
| Grant date | Sep 19, 2006 |
| Priority date | — |
| Expiry date | Oct 16, 2022 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01D2315/08
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
The present invention provides a high-resolution membrane-based method for removing a virus from a manufactured protein-containing solution, the method being particularly characterized by its capacity to be performed quickly (i.e., as measured by flux) and efficiently (i.e., as measured by log reduction value, LRV). Towards such results, the present invention employs a plurality (i.e., greater than 2) of interfacially-contiguous asymmetric ultrafiltration membranes, the foremost of which is oriented with its “tight side” facing downstream. The present invention also provides a filtration capsule, useful in the conduct of the method, comprising a pleated tube formed of three interfacially-contiguous asymmetric ultrafiltration membranes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.