Non-anaphylactic forms of allergens and their use

US7108858B2 · kind B2 · utility

Assignee

• Pharmacia Diagnostics AB · SE

Inventors

• Rudolf Valenta · Theresienfeld, AT
• Susanne Vrtala · Wien, AT
• Luca Vangelista · Padova, IT
• Hans-Georg Eichler · Wien, AT
• Wolfgang Sperr · Wien, AT
• Peter Valent · Wien, AT
• Christof Ebner · Wien, AT
• Dietrich Kraft · Wien, AT
• Hans Grönlund · Lidingö, SE

Key dates

• Filing date: Jul 3, 2001
• Grant date: Sep 19, 2006
• Expiry date: Jul 3, 2021

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/868
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is drawn to an immunogen derived from a protein allergen, which is a) a non-anaphylactic immunogenic recombinant fragment of the protein allergen which contains an IgG epitope partly but not wholly overlapping an IgE epitope of the protein allergen; b) a polymeric form of the fragment, in which the fragment constitutes the monomeric units; or c) a non-anaphylactic recombinant polymeric form of the protein allergen having 2–10 monomeric units, in which the protein allergen constitutes the monomeric units. The present invention is further drawn to the use of the immunogen for in vitro diagnoses of type I allergy and hyposensitization.