Process for reducing an alpha-keto ester
US7109004B2 · kind B2 · utility
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7Claims
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Key dates
| Filing date | Jul 8, 2003 |
| Grant date | Sep 19, 2006 |
| Priority date | — |
| Expiry date | Jan 17, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P7/62
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A process for preparing (R)-hydroxy ester (II)from alpha-keto ester Icomprising adding the alpha-keto ester I to a mixture comprising the ketoreductase enzyme and non-ketoreductase enzyme components, wherein the ketoreductase enzyme has a molecular weight between 36000 and 38000, and wherein the ketoreductase enzyme has an N-terminal amino acid sequence selected from the group of sequences consisting of
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