Method for treating heart failure by inhibiting the sarcolemmal sodium/calcium exchange
US7109169B2 · kind B2 · utility
0Cited by
2References
8Claims
0Family size
Inventors
Key dates
| Filing date | Jun 30, 2003 |
| Grant date | Sep 19, 2006 |
| Priority date | — |
| Expiry date | Aug 16, 2023 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention discloses a method of enhancing cardiac contractility in a subject with heart failure. The method consists of administering a compound that inhibits the sarcolemmal sodium/calcium exchanger, whose activity is elevated in heart failure. This method results in correction of cellular calcium handling and enhancement of cardiac contractility to healthy levels. This method can be used for treatment of acute heart failure, cardiogenic shock and congestive heart failure.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.