Substituted imidazo-pyridinones and imidazo-pyridazinones, the preparation thereof and their use as pharmaceutical compositions

US7109192B2 · kind B2 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Norbert Hauel · Schemmerhofen, DE
• Frank Himmelsbach · Mittelbiberach, DE
• Elke Langkopf · Biberach an der Riß, DE
• Matthias Eckhardt · Hannover, DE
• Roland Maier · Biberach an der Riß, DE
• Michael Mark · Biberach an der Riß, DE
• Mohammad Tadayyon · Hertford, GB
• Iris Kauffmann-Hefner · Biberach an der Riß, DE

Key dates

• Filing date: Dec 2, 2003
• Grant date: Sep 19, 2006
• Expiry date: Sep 21, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to substituted imidazo-pyridinones and imidazo-pyridazinones of general formulawherein R1 to R4 are defined as in claim 1, the tautomers, the stereoisomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).