Methods and compounds for treating proliferative diseases

US7109229B2 · kind B2 · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• Thomas Albert Engler · Indianapolis, US
• Kelly Wayne Furness · Avon, US
• Sushant Malhotra · South San Francisco, US
• Stephen L. Briggs · Clayton, US
• Harold Burns Brooks · Carmel, US
• David Clawson · Indianapolis, US
• Concepcion Sanchez-Martinez · Indianapolis, US
• Faming ZHANG · Carmel, US
• Guoxin Zhu · Noblesville, US

Key dates

• Filing date: Sep 24, 2001
• Grant date: Sep 19, 2006
• Expiry date: Dec 16, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The compounds disclosed herein are indolocarbazoles of Formula (I), which are potent CDK4 inhibitors, and are useful in the treatment of cell proliferative disorders, including cancer. Formula (I).