Stereoselective methods for the preparation of nucleosides
US7109334B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Jun 14, 2002 |
| Grant date | Sep 19, 2006 |
| Priority date | — |
| Expiry date | Jun 14, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D411/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for producing predominantly cis nucleosides or nucleoside analogues and derivatives of formula (A):wherein R1 is a pyrimidine base or a pharmaceutically acceptable derivative thereof and Q is oxygen, carbon or sulphur, comprising a coupling step of the pyrimidine base with a molecule of formula (B) described herein in a suitable coupling solvent, in the presence of catalytic amounts of an element or combination of elements of groups IB or IIB of the periodic table, a tertiary amine and a Lewis acid to obtained an intermediate of formula (D) which is deprotected in the subsequent step to generate the product of formula (A).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.