Prostaglandin synthesis

US7109371B2 · kind B2 · utility

Assignee

• Johnson Matthey Public Limited Company · GB

Inventors

• Derek Clissold · Wokingham, GB
• Stuart Wilbert Craig · Lowell, US
• Rajendrakumar Reddy Gadikota · Lowell, US
• Min He · Dongguan, CN
• Jurjus Jurayj · Acton, US
• Shahrokh Kazerani · Leominster, US
• Erwin Rannala · Ormskirk, GB
• Pradeep Sharma · Westford, US

Key dates

• Filing date: Jan 5, 2004
• Grant date: Sep 19, 2006
• Expiry date: Feb 11, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the preparation of prostaglandin compounds having the formula (I):wherein A is selected from the group consisting of C1–C6 alkyl groups; C7–C16 aralkyl groups wherein an aryl portion thereof is unsubstituted or substituted with one to three substituents selected from the group consisting of C1–C6 alkyl groups, halo and CF3; and (CH2)nOR′ wherein n is an integer from 1 to 3 and R′ represents a C6–C10 aryl group which is unsubstituted or substituted with one to three substituents selected from the group consisting of C1–C6 alkyl groups, halo and CF3; B is selected from OR″ and NHR″ wherein R″ is C1–C6 alkyl groups; andrepresents a double bond or a single bond, is disclosed. Novel intermediates are also disclosed.