Masp-2, a complement-fixing enzyme, and uses for it
US7112414B2 · kind B2 · utility
Inventors
Key dates
| Filing date | Jul 13, 2001 |
| Grant date | Sep 26, 2006 |
| Priority date | — |
| Expiry date | Jul 24, 2021 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/96433
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to substantially pure mannan-binding lectin associated serine protease-2 (MASP-2) polypeptides and fragments thereof as well as nucleic acids encoding such polpeptides. Furthermore, the present invention relates to uses of a substantially pure polypeptide comprising amino acid sequences derived from mannan-binding lectin associated serine protease-2 (MASP2) or a functional homologue thereof for the production of a pharmaceutical composition as well as pharmaceutical compositions comprising MASP-2 and/or MASP-2 fragments. In addition the present invention relates to inhibitors of MASP-2 and pharmaceutical compositions comparing such inhibitors. Methods for detecting MASP-2 nucleic acid expression are included in the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.