Process for the preparation of N-amino substituted heterocyclic compounds

US7112682B2 · kind B2 · utility

Assignee

• Aventis Pharmaceuticals Inc. · US

Inventors

• Franz J. WEIBERTH · Bound Brook, US
• George E. Lee · Somerville, US
• Reda Hanna · Allentown, US
• Juergen Mueller-Lehar · Weinolsheim, DE
• Silke Dubberke · Frankenthal (Pfalz), DE
• Roland Utz · Messel, DE

Key dates

• Filing date: Oct 1, 2004
• Grant date: Sep 26, 2006
• Expiry date: Oct 1, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

An improved process for the preparation of N-amino nitrogen heterocyclic compounds is disclosed and claimed. In an embodiment of this invention, a compound of the formula (VI) is prepared starting from the corresponding indole derivative by way of N-amination and subsequently forming an hydrazone by the reaction with a keto compound in a single step. Further reduction of the hydrazone and subsequent coupling with a pyridine compound affords the compound of formula VI or a suitable salt thereof.