4-(c2-6alkoxy)-substituted chalcones as therapeutic agents

US7112698B2 · kind B2 · utility

Assignee

• Spear Therapeutics Limited · GB

Inventors

• Gerard Andrew Potter · Leicester, GB
• Taeeba Ijaz · Leicester, GB

Key dates

• Filing date: Sep 30, 2002
• Grant date: Sep 26, 2006
• Expiry date: Sep 30, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C45/74
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention pertains to compounds of the following formula: (1) wherein: RALK is primary or secondary aliphatic saturated C2-6alkyl; each of RB2, RB3, RB4, and RB5 is independently —H, —OH, or —OMe; each of R1 and R2 is independently: —H, optionally substituted C1-4alkyl, or optionally substituted C5-20aryl; RA3 is —H, —OH, —OC(═O)RE, —OS(═O)2OH, or —OP(═O)(OH)2; RE is: —H, optionally substituted C1-6alkyl, optionally substituted C3-20heterocyclyl, or optionally substituted C5-20aryl; or a pharmaceutically acceptable salt, solvate, amide, ester, ether, chemically protected form, or prodrug thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, for both diagnosis and treatment of, for example, proliferative conditions, such as cancer, and inflammatory conditions