Particle formation methods and their products
US7115280B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 1, 2001 |
| Grant date | Oct 3, 2006 |
| Priority date | — |
| Expiry date | Dec 3, 2022 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/1652
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Preparation of particles of an active substance having a layer of an additive at the particle surfaces, by dissolving both the active substance and the additive in a vehicle to form a target solution, and contacting the target solution with an anti-solvent fluid using a SEDS™ particle formation process, to cause the active substance and additive to coprecipitate. The additive is typically a protective additive, in particular a taste and/or odour masking agent. Also provided is a particulate coformulation made by the method, which has a finite gradient in the relative additive concentration, which concentration increases radially outwards from the active-rich core to the additive-rich surface of the particles.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.