Process for the preparation of optically active 7-substituted-3-(2-aminopropyl)indole derivatives and intermediates therefor
US7115412B2 · kind B2 · utility
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Key dates
| Filing date | Mar 30, 2001 |
| Grant date | Oct 3, 2006 |
| Priority date | — |
| Expiry date | Jan 2, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P17/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed are a process for preparation of an optically active 7-substituted 3-(2-aminopropyl)indole compound and an intermediate therefor. In the above preparation process, 7-substituted indole is reacted with L- or DL-serine in the presence of a tryptophan-synthesizing enzyme originating in microorganisms to form corresponding 7-substituted L-tryptophan, and it is subjected, if necessary, to reduction, protection, exchange and elimination.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.