Substituted piperazinyl amides and methods of use

US7115607B2 · kind B2 · utility

Assignee

• AMGEN INC. · US

Inventors

• Christopher H. Fotsch · Thousand Oaks, US
• Premilla Arasasingham · Thousand Oaks, US
• Yunxin Y. Bo · Thousand Oaks, US
• Ning Chen · Thousand Oaks, US
• Martin Goldberg · Big Bear City, US
• Nianhe Han · Newbury Park, US
• Feng-Yin Hsieh · Thousand Oaks, US
• Michael G. Kelly · Thousand Oaks, US
• Qingyian Liu · Camarillo, US
• Mark H. Norman · Thousand Oaks, US
• Duncan M. Smith · Thousand Oaks, US
• Markian Stec · Thousand Oaks, US
• Nuria A. Tamayo · Newbury Park, US
• Ning Xi · Newbury Park, US
• Shimin Xu · Beijing, CN

Key dates

• Filing date: Jul 24, 2002
• Grant date: Oct 3, 2006
• Expiry date: Aug 5, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Selected substituted piperazine compounds of Formula I are effective for prophylaxis and treatment of diseases, such as obesity and the like. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving activation of the melanocortin receptor. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.