Patent · US Expired

Anti-TRAIL-R antibodies

US7115717B2 · kind B2 · utility

45Cited by
4References
14Claims
0Family size

Assignee

Inventors

Key dates

Filing dateMay 17, 2002
Grant dateOct 3, 2006
Priority date—
Expiry dateDec 26, 2022

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07K2317/73
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Anti-TRAIL-R1 and R2 antibodies or functional fragments thereof, having at least one property selected from the following (a) to (c) of:(a) having activity to induce apoptosis in carcinoma cells expressing TRAIL-R1 and/or TRAIL-R2;(b) not having effect on normal human cells expressing TRAIL-R1 and/or TRAIL-R2; and(c) not inducing human hepatocyte toxicity.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.