L-methionine $g(g)-lyase with modified function
US7118903B2 · kind B2 · utility
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14Claims
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Key dates
| Filing date | Aug 24, 2001 |
| Grant date | Oct 10, 2006 |
| Priority date | — |
| Expiry date | Oct 30, 2022 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An L-methionine γ-lyase having modified function which is obtained by structurally stabilizing natural L-methionine γ-lyase by analyzing the structure of crystals thereof by using X-ray, estimating an amino acid sequence concerning its substrate specificity and varying amino acid residue thereof; enzymes comprising a protein constituting the L-methionine γ-lyase having modified function or its multimer (preferably its tetramer); DNA sequences encoding these enzymes; a process for producing these enzymes; and medicinal preparations (preferably anticancer agent) containing these enzymes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.