Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade

US7119094B1 · kind B1 · utility

Assignee

• WARNER-LAMBERT COMPANY LLC · US

Inventors

• Michael S. South · Chesterfield, US
• John J. Parlow · Arnold, US
• Darin E. Jones · Ballwin, US
• Brenda Case · Chesterfield, US
• Tom Dice · Holden, US
• Richard Lindmark · Chesterfield, US
• Michael Hayes · Chesterfield, US
• Melvin L. Rueppel · Chesterfield, US
• Rick Fenton · Collinsville, US
• Gary W. Franklin · Godfrey, US
• Horng-Chih Huang · Chesterfield, US
• Wei Huang · Wildwood, US
• Carrie Kusturin · Edwardsville, US
• Scott Long · Holden, US
• William L. Neumann · Chesterfield, US
• David B. Reitz · Chesterfield, US
• John I. Trujillo · Ledyard, US
• Ching-Cheng Wang · New Taipei, TW
• Rhonda Wood · Maryland Heights, US
• Qingping Zeng · Thousand Oaks, US
• Matthew Mahoney · Saint Peters, US

Key dates

• Filing date: Nov 20, 2000
• Grant date: Oct 10, 2006
• Expiry date: Feb 24, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.