Heteroarylakanoic acids as intergrin receptor antagonists

US7119098B2 · kind B2 · utility

Assignee

• Pharmacia Corporation · SE

Inventors

• Srinivasan Nagarajan · Arlington Heights, US
• Ish Khanna · Vernon Hills, US
• Michael B. Tollefson · Dardenne Prairie, US
• Scott Mohler · Chicago, US
• Barbara Chen · Braintree, US
• Mark Russell · Skokie, US
• Balekudru Devadas · Chesterfield, US
• Thomas D. Penning · Elmhurst, US
• Lori A. Schretzman · Gurnee, US
• Dale P. Spangler · Deerfield, US
• Mark Laurence Boys · Lyons, US
• Nizal Chandrakumar · North Grafton, US
• Hwang-Fun Lu · Ballwin, US

Key dates

• Filing date: Jun 15, 2001
• Grant date: Oct 10, 2006
• Expiry date: Jun 15, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a class of compounds represented by formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of Formula (I), and methods of selectively antagonizing the ανβ3 and/or the ανβ5 integrin without significantly antagonizing the IIb/IIIa integrin.