P. aeruginosa mucoid exopolysaccharide specific binding peptides
US7119172B2 · kind B2 · utility
1Cited by
15References
39Claims
0Family size
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Inventors
Key dates
| Filing date | May 16, 2003 |
| Grant date | Oct 10, 2006 |
| Priority date | — |
| Expiry date | Aug 17, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/565
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to P. aeruginosa mucoid exopolysaccharide. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of P. aeruginosa infection and related disorders (e.g., cystic fibrosis). Some antibodies of the invention enhance opsonophagocytic killing of multiple mucoid strains of P. aeruginosa. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.