Metabotropic GABA [B] receptors, receptor-specific ligands and their uses

US7119189B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Klemens Kaupmann · Bad Kötzting, DE
• Bernhard Bettler · Allschwil, CH
• Helmut Bittiger · Glückstadt, DE
• Wolfgang Frostl · Basel, CH
• Stuart J. Mickel · Lausen, CH

Key dates

• Filing date: Jun 6, 2001
• Grant date: Oct 10, 2006
• Expiry date: Jun 6, 2021

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/20
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention provides purified GABAB receptors and receptor proteins derived from rat and human sources, as well as nucleic acids which encode such proteins. The proteins and nucleic acids of the invention share significant homology with the GABAB receptor and the DNA encoding it as specifically disclosed herein. The invention moreover provides methods for isolating other members of the GABAB receptor family using DNA cloning technology and probes derived from the sequences provided herein, as well as novel members of the GABAB receptor family isolated by such methods.Furthermore, the invention relates to the use of GABAB receptors and receptor proteins and cells transformed with a gene encoding a GABAB receptor protein in a method for identifying and characterising compounds which modulate the activity of the GABAB receptor, such as GABAB receptor agonists and antagonists, which may be useful as pharmacological agents for the treatment of disorders associated with the central and peripheral nervous systems.