Process for the preparation of tolterodine and intermediates thereof
US7119212B2 · kind B2 · utility
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19Claims
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Key dates
| Filing date | Mar 29, 2005 |
| Grant date | Oct 10, 2006 |
| Priority date | — |
| Expiry date | Mar 29, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D311/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the preparation of 6-methyl-4-(R)-phenyl-chroman-2-one and 6-methyl-4-(S)-phenyl-chroman-2-one, intermediates for the synthesis of tolterodine and its (S) enantiomer, by reaction of 6-methyl-coumarin with phenylboronic acids, esters and derivatives thereof, in the presence of chiral catalysts.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.