Method and apparatus for engineered regenerative biostructures such as hydroxyapatite substrates for bone healing applications

US7122057B2 · kind B2 · utility

Assignee

• Therics, LLC · US

Inventors

• Heather Ann Beam · Penndel, US
• Thomas J. Bradbury · Yardley, US
• Kathleen Chesmel · Cream Ridge, US
• Christopher M. Gaylo · Princeton Junction, US
• Alfred Litwak · Keyport, US
• Qing Liu · Beijing, CN
• Peter Materna · Metuchen, US
• Donald C. Monkhouse · Radnor, US
• Jennifer Patterson · Seattle, US
• Timothy J. Pryor · Yardley, US
• Sunil Saini · Monroe, US
• Henry L. Surprenant · Phoenixville, US
• Chen-Chao Wang · Kaohsiung, TW
• Thomas G. West · Lawrenceville, US
• Jaedeok Yoo · Princeton, US

Key dates

• Filing date: Apr 12, 2002
• Grant date: Oct 17, 2006
• Expiry date: Mar 19, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C04B2235/96
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

An engineered regenerative biostructure (erb) for implantation into a human body as a bone substitute, which includes an internal microstructure, mesostructure and/or macrostructure to provide improved bone in-growth, and methods for making the erb. Under one aspect of the invention, the biostructure has resorbable and nonresorbable regions. Under another aspect of the invention, the biostructure is constructed of hydroxyapatite, tricalcium phosphate and/or demineralized bone. Under yet another aspect of the invention, the porous biostructure is partially or fully infused with a resorbable, nonresorbable or dissolvable material.