Specific monoclonal antibody against terbinafine

US7122184B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Birgit Dorobek · Schopfheim, DE
• Peter Nussbaumer · Schwanenstadt, AT

Key dates

• Filing date: Feb 12, 2001
• Grant date: Oct 17, 2006
• Expiry date: Aug 22, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/646
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention concerns momoclonal antibodies to terbinafine in free base or salt form, immunogenic conjugates suitable for preparing them, hybridoma capable of producing them, and corresponding assay kits. The antibodies can be prepared by administering to an appropriate animal an immunogenic conjugate of a suitable derivative of terbinafine covalently linked to an immonogen, recovering antibody-producing cells sensitized to the conjugate, immortalizing the antibody-producing cells, selecting a resultant immortalized cell line, and recovering the resultant antibodies therefrom. They are indicated for use in particular in the measurement of terbinafine tissue concentration and distribution in bodily fluids or compartments, especially nails.