Method for producing biaryl compound
US7122711B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 15, 2002 |
| Grant date | Oct 17, 2006 |
| Priority date | — |
| Expiry date | Oct 4, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2531/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There is disclosed a method for producing a biaryl compound of formula (I):wherein R1 is the same or different and independently denotes a substituted or unsubstituted hydrocarbon group or the like, A and B denote an aromatic hydrocarbon ring having from 6 to 14 carbon atoms or the like, k and m independently denote an integer of from 0 to 5, and l denotes an integer of 1 or 2, which method is characterized by reacting an aromatic compound of formula (II):wherein R1, k and l denote the same as defined above, and X1 denotes a leaving group, with a Grignard reagent of formula (III):wherein R2, B, and m denote the same as defined above and X2 denotes chlorine or the like, in the presence of a cyclic ether, or an acyclic ether having two or more ether oxygens in the molecule and a nickel catalyst.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.