Combined methods for tumor vasculature targeting and tumor treatment with radiotherapy
US7125541B2 · kind B2 · utility
69Cited by
62References
15Claims
0Family size
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Key dates
| Filing date | Dec 14, 2000 |
| Grant date | Oct 24, 2006 |
| Priority date | — |
| Expiry date | Jan 13, 2022 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/828
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the vasculature of solid tumor masses through recognition of tumor vasculature-associated antigens, such as, for example, through endoglin binding, or through the specific induction of endothelial cell surface antigens on vascular endothelial cells in solid tumors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.